|Year : 2022 | Volume
| Issue : 2 | Page : 73-74
Vishnu Sharma Moleyar
Department of Respiratory Medicine, A.J. Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India
|Date of Submission||13-Jun-2021|
|Date of Acceptance||03-Jul-2021|
|Date of Web Publication||17-May-2022|
Dr. Vishnu Sharma Moleyar
Department of Respiratory Medicine, A.J. Institute of Medical Sciences and Research Centre, Kuntikana, Mangalore, Karnataka
Source of Support: None, Conflict of Interest: None
Intra thoracic tumors can lead to a variety of para-neoplastic manifestations which is often overlooked. Awareness about the para-neoplastic manifestations and the possible intra thoracic causes for the same will lead to early diagnosis and appropriate management. In this self assessment quiz we have discussed regarding the para-neoplastic manifestations in Carcinoid tumor.
Keywords: Atypical carcinoid, carcinoid syndrome, carcinoid tumor, intra thoracic tumors, paraneoplastic manifestations
|How to cite this article:|
Moleyar VS. Self-assessment quiz. J Adv Lung Health 2022;2:73-4
1. A 46-year-old female is admitted for evaluation of mediastinal mass. On physical examination, she is found to have typical moon face, buffalo hump, centripetal obesity, skin pigmentation, proximal muscle weakness, and hirsutism. Her blood pressure is found to be 180/100 mmHg and her blood sugar is 340 mg/dl. She was not a known hypertensive or diabetic. She had no premorbid illness. She was not on any medications. No history of any addictions or illicit drug abuse. What is the MOST LIKELY diagnosis of mediastinal mass?
- Thymic carcinoid
- Neurogenic tumor
- Hodgkin's lymphoma
- Germ cell tumor.
Answer – B. Physical findings are typical of Cushing's syndrome. Cushing's syndrome is known to cause hirsutism, hypertension, and diabetes mellitus. Endogenous Cushing's syndrome is mainly due to adrenocorticotropic hormone (ACTH) secreting pituitary adenomas – (75% to 80%), adrenal neoplasms (10%–15%), and ectopic ACTH secretion (10%). Ectopic sources of ACTH include small cell carcinoma of the lung and neuroendocrine tumors such as bronchial and thymic carcinoid and rarely gastrointestinal tract carcinoids.
2. A 28-year-old male patient is admitted for evaluation of intermittent episodes of flushing of the face, breathlessness, diarrhea, and palpitation. Physical examination showed reduced breath sounds on right hemithorax. Chest x-ray revealed partial collapse of the right lung. Bronchoscopy revealed endobronchial lesion partially occluding the right main bronchus. What is the MOST LIKELY diagnosis?
- Carcinosarcoma of lung
- Squamous cell carcinoma of the lung
- Large cell carcinoma of the lung
- Carcinoid tumor
- Adenocarcinoma of the lung.
Answer – D. Flushing of face, breathlessness, diarrhea, and palpitation are typical symptoms of carcinoid syndrome. Flushing is the most common symptom in carcinoid syndrome.
3. Which is a WRONG statement about carcinoid tumours?
- Most common site is the ileum
- Carcinoid syndrome is rare
- Bronchial carcinoid commonly associated with MEN type 2
- Carcinoid syndrome is more common in malignant carcinoid
- Lung carcinoid can produce carcinoid syndrome without liver metastasis.
Answer – C. 5% to 10% of cases bronchial carcinoid may be associated with MEN type 1. MEN type 1 is characterized by the combination of parathyroid tumors, pancreatic islet cell tumors, and anterior pituitary tumors. It was initially known as Wermer syndrome, described in 1954 by Wermer.
4. Which of the following is NOT seen in carcinoid syndrome?
- Mesenteric fibrosis
- Abdominal pain
- Left ventricular failure.
Answer – E. Carcinoid syndrome can lead to deposition of fibrous tissue on the tricuspid valve leading to stenosis and right heart failure. Left heart involvement is rare as 5 Hydroxytryptophan is inactivated in the lungs before it reaches the left heart. More than 40 hormones and vasoactive substances have been found to be secreted by carcinoid tumors. Serotonin (5-HT), histamine, kallikrein, prostaglandins, and tachykinins are the main substances responsible for the clinical manifestations of carcinoid syndrome. Up to 80% of well-differentiated carcinoid tumors express somatostatin receptors on their cell surface. Somatostatin analogs namely octreotide and lanreotide are the mainstay of treatment for carcinoid syndrome. Somatostatin analogs bind to the somatostatin receptors and inhibit the secretion of several hormones and vasoactive substances, thus improving flushing and diarrhea symptoms. Octreotide in depot form can be administered intramuscularly at a dose of 20 to 30 mg once in every 4 weeks. Lanreotide is administered subcutaneously at a dose of 120 mg every 4 weeks.
5. Which of the following is a WRONG statement regarding atypical carcinoid tumor of the lung?
- Less common compared to typical carcinoid
- More aggressive compared to typical carcinoid
- Majority are central in location
- More common after age 60 years
- Usually larger in size on diagnosis compared to typical carcinoid.
Answer – C. Majority of atypical carcinoids are peripheral in location. Because of the peripheral location, they remain asymptomatic for a long time. Symptoms appear only when they attain large size leading to the involvement of surrounding structures.
6. Which is a WRONG statement regarding mediastinal lesion?
- The most common paraneoplastic syndrome associated with Thymoma is myasthenia gravis
- Pain after alcohol ingestion is seen in Hodgkin's lymphoma
- Hypercalcemia may occur in lymphoma
- Recurrent infections can be the manifestation of Neurogenic tumor
- Fevers, night sweats, and weight loss are classically seen with lymphoma.
Answer – D. Thymoma can cause hypogammaglobulinemia which can lead to recurrent skin and respiratory infections due to reduced immunity. Neuroblastoma can lead to diarrhea due to vasoactive intestinal peptides secreted from the tumor.
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Conflicts of interest
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